A recent study reveals that patients who stop using blockbuster weight-loss injections like semaglutide or tirzepatide may regain lost weight much more quickly than those who halt traditional diet and exercise regimens.
Research printed in a prominent medical journal demonstrates that while overweight people can lose a large proportion of their total mass while undergoing treatment, the mass comes back at an average rate of nearly a kilo each month upon discontinuation.
"People buying these drugs need to be cognizant of the risk of rapid weight regain when the medication concludes," warns lead investigator Dr. Susan Jebb.
That rate of regain implies a return to original weight in about 18 months.
Weighing Approaches
The analysis, which reviewed dozens of studies involving over 9,000 of patients, contrasted the results of the injectable medications with conventional dieting.
The team point out that individuals who shed pounds through dieting typically experience a less rapid weight regain—perhaps 0.1 kg a month—post-intervention.
Understanding the Fast Regain
Experts suggest the mode of action of the drugs is key to understanding the amplified weight return.
These medications imitate a body's own chemical called glucagon-like peptide-1, which moderates hunger.
"Long-term administration of GLP-1 concentrations far above than normal may cause the body to generate a reduced amount of its endogenous hormone, and may also lessen sensitivity to its effects," said Dr. Adam Collins, a nutrition specialist.
"Discontinuation of this GLP-1 'fix' leads to appetite is unsuppressed, making binge eating a significant risk."
An Ongoing Condition?
The NHS recommend the injections for people with obesity-related health risks, accompanied by prescribed diet and exercise modifications.
A number of clinicians say that, due to the significant potential of weight regain, the treatment might need to be long-term.
This opinion is echoed by drug manufacturers, who say that the findings "emphasize the chronic nature of obesity," comparing it to managing diseases like diabetes.
Patient Accounts
People who have come off the jabs describe a sudden return of appetite.
"It was like something activating and you're instantly ravenous," said a patient.
This difficulty is compounded if individuals have not established lasting lifestyle or habit modifications during therapy.
Widespread Adoption
Figures suggest that a significant number of people in the UK have used these injections in the past year, with demand remaining high.
- Use is greater among females compared to males.
- The 40s and 50s age group shows the greatest usage rates.
- Many access the drugs through private healthcare rather than the NHS.
Finally, experts stress that while the jabs are potent tools for shedding pounds, they are not a permanent fix and maintained weight loss relies on integrated behavioural changes.
